| Name |
Views and Comments | Date |
| Harry Horton |
The article was 'prediabetes the calm before the storm', an article under the (9) number category of article listings. That commentary could be relevant to the one below.
One of the fascinating issues, as far as I am concerned when considering the anti oxidant issue, and its fairly primary relevance to disease states---states ranging from diabetes, hypertension, cancer even aging processes ect.----deals with the phenomena of cytokines. Cytokines are an integral biochemical component within the immune response. But, the issue at hand, are cytokines misperceived by the medical research community, that is their function and presence, as taught by standard medical school curriculumn. And one of the reasons for this, is that researchers were able to halt diabetes in mice by inhibiting a particluar immune response called macrophage inhibitory factor (MIF). MIF involves a substantial cytokine essence to its activity when it goes into operation. Macrophage Inhibitory Response involves macrophages migrating to fat tissue areas, congregating there, and also the macrophages release a lot of inflammatory chemicals that are harmful generally to the body. Cytokines are fairly replete in their activity with such a MIF response. Diabetes was able to be cleared up in mice by inhibiting the MIF response. But here is where an interesting conflictory situation occurs. Leptin, a biochemical entity secreted by adipocyte cells was found to be structurally similar to the class of cytokines. In fact leptin has an active site similar to the biochemical entity (IL)-6, Ineterleukin 6. Leptin has also been involved in receding and dissipating diabetes also, such as research from Mt. Sinai. The issue that needs to be clarified, since leptin is involved in appetite, fat development, and the like, and most importantly plays a role in regulating energy production processes, than the cytokines in the oxidant producing areas, such as the case with MIF are primarily involved with energy production processes in mitochondrial functions also. That is, as opposed to the fact that macrophages along with their constiuent cytokine activity and inflammatory response dynamics, being essentially simply an immune response taking part in going after antigens in the immune response process. This macrophage cytokine immune response has more to do with mitochondrial energy production dynamics no different essentialy than the activity of leptin. Thus leptin and the MIF cytokines are structurally the same, being of the cytokine family and as such--- 'why should not their activity essentially be the same'. Activity primarily focused on mitochondrial energy dynamics and production involving areas as regulation of such energy areas and what modes of functions electron transport chain operations take on, ---the latter involvoing uncoupling protein expression, the nature of ATP hydrolysis concommitant with ATP resynthesis ect.--- I think that this is a central issue involving how medical research views leptin and the other cytokines one finds in the immune responses. And not overly assigning cytokine functions as a component part of engaging antigens in the unfolding immune response. As a primary role for cytokines, that is. Rather, should researchers replace such a concept with the one, that these immunological cytokines are primarily responsible for their role in participating with mitochondrial energy processes instead. And further extending that concept back to glycolytic processes as well. Thus, the known processes of leptin could be a model for understanding how the other immunological cytokines function. That would be a very interesting development in medical science studies, if the theories above hold any weight. Thus anti oxidant processes could be more central to energy production with the mitochondria in focus, for determining the primacy of their therapeutic effects. Even though anti oxidants are currently known to be more relevant to immune responses and the inflammatory response, generally by the population. A view that may not be extensive enough. |
5/14/2007 |
| Darren Little |
The world's first anti-aging coffee and anti-aging tea can be purchased now ONLINE. Distributors needed. Contact Darren Little at 604-771-1901 |
1/5/2007 |
| jean leaman |
instead of the pill form, can you just grind and use the green coffee bean as coffee, would you get the same effect. I have just started doing that, and am waiting to see what happens. |
10/3/2006 |
| diana bickford |
I found this article informative and useful. |
5/21/2006 |
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