| Name |
Views and Comments | Date |
| angela |
Excellent article, easy to understand. Since we know obesity and insulin resistance are the reason for the Type 2 diabetes epidemic; we should concentrate on prevntion by healthy life style modications at an early age. |
6/26/2007 |
| Harry Horton |
Atypical antipsychotic (AAP)drug induced conditions of hyperglycemia and diabetes, present an interesting picture upon how certain diabetes conditions could develop. And its a picture that is far from being understood, though some points and facts are appearing for greater understanding of the hyperglycemic conditions.
Some AAP hyperglycemia conditions appear without any change in insulin resistance in the patients. Furthermore, insulin resistance is in the healthy range, though substantially elevated in the healthy range. A study done by the researcher- Howe -on olanzapine, found that fact out. Glucose transport has been validated to be diminished in rat adipocytes by 50-70% by clozaril and risperidone usage, a June 2006 study, done by the rearcher Vestri of the University of Alabama Birmingham, found that fact out. Also, AAP diabetes develops without weight gain in some cases.
One interesting fact that researchers found was that leptin elevations of a substantial degree, developed at the outset of some AAP usage cases, that eventually heralded diabetes development in as little as six to eight weeks. Leptin regulates energy homeostasis, appetie and fat development in some people. And yet, it is the first disturbance in AAP induced cases of hyperglycemia. An article, by the author Marie Lofthouse entitled--"Leptin predicts Metabolic Syndrome", gives an interesting account of the dynamics of leptin and how it predicts metabolic syndrome development conditions in patients. And in AAP cases, leptin turns out to be the initiating substantial irregularity that brings on eventual diabetes and hyperglycemia in AAP patients. Its unusual that insulin resistance and Free Fatty Acids have not held much prominence by many researchers in these rapidly developing diabetes conditions from AAP usage. Free fatty acids have not been emphasized by many researchers, and the surprising finding that insulin resistance stays unchanged along with Body Mass Index, while insulin stimulated glucose homeostasis becomes substatnially impaired is interesting. Even more interestingly, when insulin resistance goes up eventually in AAP cases, glucose transport goes down. In a usual diabetes case, glucose transport goes up in a correlative fashion with insulin resistance rise in order to compensate for overcoming the resistance. But the opposite happens in AAP cases. However fat gain has been noted by researchers, (Marilyn Ader, journal -Diabetes March 2005) but the fact that diabetes develops sometimes with no weight gain caught the eye of a lot of researchers.
All in all, atypical antipsychotic induced conditions of hyperglycemia and diabetes will offer a novel understanding of how hyperglycemia and diabetes develops as research in the years ahead tries to grapple with the biological facts of the condition. Many traits of a usual diabetes progression are absent in the AAP induced cases. And a lot of medical surprises of the underlying metabolic dynamics that encompass AAP hyperglycemic conditions have been noted. So furthering research in AAP hyperglycemic conditions in the futrue will certainly turn up many more new insights on how diabetes develops. |
5/22/2007 |
| Tiffany S. |
This article summarizes the relationship between free fatty acids, obesity and insulin resistance very well. I have been doing research on this topic and this article is one of the best summaries I have found so far. Thanks! |
3/6/2007 |
|
