| Name |
Views and Comments | Date |
| Harry Horton |
A diabetes Puzzle:
A good deal of recent research has upturned a good number of facets concerning the disorder diabetes: inflammatory conditions, mitochondrial mutations, dysfunctions in the central nervous system are some of the various examples of areas in the body that could house the origins or at least substance of the disease. There are four studies that present a puzzle of about how diabetes operates.
The first study involves a research finding from Mt. Sinai medical center, involving Charles Mobbs work with leptin in the hypothalamic areas of rats. The study was written up in the journal Diabetes, November 2003 edition. He took a thearpeutic entity and boosted the energy levels at a hypothalamic gene called POMC of diabetic mice. The result was the mice, regained normal insulin sensitivity and renormalization of glucose levels. Their diabetes simply disappeared. More interestingly, the rats eradicated diabetes while remaining morbidly obese. (2) The second study was the eradication of diabetes in Toronto Canada, Sick Children's Hospital,
accomplished in a medical report to the journal Cell, December 15, 2006. Capsaicin treatemnts of the pancreatic islet cell nerves, eradicated insulin resistance and the substance of diabetes I activity, of the finalized destructive attack feature, in mice. Diabetes disappeared in that study also. Thus, the Toronto study is a second area of dynamics of diabetes, that will comprise and add substance to the puzzle. (3) Joslin study, from the earlier part of the decade. A master switch within the iinflammatory response was discovered, such a switch determined the development of insulin resistance. The result of the study was, low level dimuted inflammatory conditions must be present and constant in the body as a prerequisite condition for insulin resistance to develop. And once insulin resistance develops, glucose dysregulation sets in creating diabetes II development. The fourth condition (4) MIF (macrophage inhibitory factor), once quelled in mice eradicates diabetes in some studies. What is interesting about this study is that when fat tissue develops in obese people with diabetes, macrophages congregate at a site where they release cytokines as a component of the inflammatory response. Macrophage inhibitory factor (MIF) plays a role in this response of congregating macrophages at the fat site.(5) Atypical antipsychotics create hyperglycemia and diabetes in mental patients. A PNAS study discovered that quadrupled AMPK amounts occured in mice hypothalamic areas as the result of the administration of these agents. A leptin based therapeutic was adminstered to the rats. The AMPK levels returned to normal suggesting the metabolic irregualrities could be reileved by the leptin based therapeutic. That is data waiting further exploration though for further validation. This therapeutic activity is roughly similar to the Mt. Sinai treatment at (1).
The Mt. Sinai treatment contained obese rats whose diabetes disappeared. Yet their obesity remained and most likely the inflammatroy condition was intact. Though this feature has not been clarified scientifically, but most likely by inference, the inflammatory condition was still operable in the obese rats. The Joslin study however stated in order to eradicate diabetes one must eradicated the low level inflammatory response in order to diminish the insulin resistance and thus cure diabetes. In the Toronto sick Childrfen's Hospital Study, the systemic persistance pools of pathogenic T cells were still in activity in the rats cured of diabetes. The immune attack along with constiuent inflammatory responses were still active in this study. Yet diabetes diappeared in such rats. With the atypical antipsychotic AMPK studies, the hypothalmic areas were centered on with leptin to return metabolic irregularities of obesity back to normal body composition, with the leptin. Suggesting hyperglycemia, too could be cleared up. A similar approach to the Mt. Sinai treatments. So how can diabetes be cleared up with such conflictory and contradictory means, with the various enumerated approaches. Its a puzzle. Leptin and its strucutre is constructed similarly to cytokines. It is homologous to the cytokine class of biological entities. With Macrophage Inhibitory Factor (MIF), cytokines play a major role in maintaining the essence and continuance of the diabetes II condition. Other studies have suggested leptin dynamics peresist in the development of diabetes and metabolic syndrome. Abnormal amounts of leptin activity do indeed appear at the outset of atypical antipsychotic induced diabetes cases. One result of the puzzle, the macrophage cytokine acitivy appears to be more closely allied to mitochondrial energy producing functions along with leptin. And that could be a possible area for researchers to consider in the future, if such a highly theoretical approach holds any factual validity to it. In the Mt. Sinai treatments,
boosting mitochodrial energy processes eliminated diabetes though obesity and inflammatory conditions persisted. With MIF, quelling macrophage activity with allied cytokine activity, could have had a backward cause and effect activity of creating more energy production of the health status in the mitochondria, taking diabetes away with such a function. Macrophage activity, with constiuent inflammatory processes along with cytokine activity, thus plays more of a role connected to mitochondrial energy production status in such a scenario. That could possibly be in this previous highly theoretical assertion. And leptin was used in the atypical antipsychotic AMPK example to renormalize metabolic conditions. Leptin is scientifically validated to affect energy balance in the cells. So the result could be concerning the Joslin study, that the inflammatory response is still heavily tied into mitochodnrial energy production status for its therapeutic effects when centered on for eradicating diabetes. These above facts and assertions still would require much needed research efforts in the future to validate their legitamacy. |
5/11/2007 |
| deanerick |
following a strict carb diet is essential for those with diabetes, and even those without...... |
2/6/2005 |
| deanerick |
diabetes is very important to check for, i agree. if your family has a history, even more reason to get checked regularly..... |
2/6/2005 |
| sumnguy |
It is very dangerous. |
1/2/2005 | |
