Serotonin Syndrome Treatment

Serotonin is a chemical, that acts as a neurotransmitter in the human body. It is found in the central nervous system, gastrointestinal tract and platelets. Some of the most vital functions (like, sleep, muscle contractions, appetite, mood variations, memory, etc.) of the body are regulated by serotonin and so, an increase or decrease in normal serotonin levels may affect these functions. This results in mild to severe symptoms, that can be sometimes life-threatening too. While, low serotonin levels are found to cause depression, high levels of this chemical in the body causes serotonin syndrome.

What Causes Serotonin Syndrome

As mentioned above, high levels of serotonin in the body is the basic cause for the occurrence of serotonin syndrome. A rise in serotonin levels is usually caused by antidepressant drugs. These drugs are usually used for elevating the serotonin levels, in people who face depression. Some people develop this condition, when they consume antidepressants for the first time. In case of people, who already use these drugs, serotonin syndrome can be caused by a sudden increase in their daily dosage. However, the most common among the serotonin syndrome causes is the intake of more than one antidepressant or taking an antidepressant along with other medication (like migraine medicines), herbal remedies (like St John's wort), illicit drugs (cocaine, LSD, etc.) or dietary supplements that can increase the levels of serotonin in the body.

Serotonin Syndrome Symptoms

The symptoms of serotonin syndrome can range from mild to severe and even life-threatening. Symptoms appear within few minutes or hours after ingestion of the drugs. While mild symptoms include sweating, shivering, slight rise in body temperature, nausea, dilated pupils, etc. moderate ones include high blood pressure, high body temperature, mental confusion, tremors, agitation, etc. Severe cases of serotonin syndrome may cause symptoms, like unconsciousness, sudden rise in blood pressure and heart rate, high body temperature (around 106 °F), hyperthermia, etc. Severe symptoms may lead to life-threatening conditions, like coma, renal failure rhabdomyolysis, etc. and so, immediate serotonin syndrome treatment must be provided for the affected people.

How is Serotonin Syndrome Treated

In some cases, mild symptoms of serotonin syndrome may go unnoticed, whereas in others, stopping the use of offending medicines (only as per the advice of the doctor) may provide relief from the symptoms. However, moderate to severe symptoms require immediate medical attention. The diagnosis of serotonin syndrome is usually based on the medical history of the affected person, especially, the types of drugs used by him/her. The affected person must experience at least three to four symptoms of serotonin syndrome. Apart from that, some other tests will be conducted, so as to rule out the possibility of other conditions, like intoxication, infections, drug withdrawal, etc.

• In case of mild symptoms, stopping the usage of the offending drug or decreasing the dose may be sufficient to get relief from the symptoms. However, this must be done as per the instructions of your doctor.
• Moderate to severe symptoms require hospitalization, as close monitoring of the patient is required. Serotonin syndrome treatment is mainly aimed at resolving the symptoms.
• The affected person may be administered with muscle relaxants for symptoms like seizures, agitation, muscle stiffness, etc. Other medication include drugs to normalize high blood pressure and rapid heart rate.
• In case of hyperthermia or heat stroke, aggressive cooling techniques, like ice packs and water sprays will be required to bring down the high body temperature.
• Some of the severely affected patients may need medication to block the production of serotonin, so as to normalize the serotonin levels in the body.
• Treatment for serotonin syndrome includes intravenous fluids that are used to bring down the fever and for avoiding dehydration.

It is always better to avoid this condition by refraining from self medication. While treatment must be provided immediately for people with severe symptoms, even mild symptoms may get worse, if left untreated. So, it is always better to consult the doctor, if you experience any such symptoms. If you are a person, who is taking antidepressants, then avoid usage of other medication, without the consent of your doctor. Others too must go through the warning labels, before taking any drugs.