Methotrexate Injection

Methotrexate is a drug that falls under the class of drugs known as anti metabolites. Now you may be wondering what is methotrexate used for? Apart from being used as a chemotherapy treatment drug, it is also used to cure psoriasis and rheumatoid arthritis. In some cases, methotrexate shots are also used for medical termination of pregnancy (MTP). This medication slows down the growth of certain cells in the body, but may not be helpful in curing the disease. This injection is also an antifolate drug since it inhibits or slows down the metabolic rate of folic acid. This medication is quite effective when it comes to treating ailments like arthritis, postural psoriasis, Crohn's disease, ankylosing spondylitis and scleroderma. The methotrexate injection cost depends on the dose and strength of the medication. The prices range from approximately USD 24 for a 2 mL vial up to USD 250 for 20 mL.

Methotrexate Dosage

The dose for methotrexate must be taken as advised by the doctor to avoid any possible side effects of an overdose. According to the doctors, this injection can be taken either once or twice per week depending on the ailment. The dosage for psoriasis and rheumatoid arthritis is lesser than the dose taken for any type of cancer. Apart from injections, methotrexate also comes in the form of 2.5 mg tablets. The maximum dose for an adult is approximately 7.5 to 10 mg. In case of rheumatoid arthritis, a single tablet can be taken per day. If you forget to take the drug, don't take it the next day. Instead continue the dose on the next scheduled day. Never take more than one dose on the same day, unless prescribed by the physician, as it may be deteriorating to the health. Remember to store this medication in a cool, dry place and away from sunlight. Avoiding keeping this drug in places where it can be easily accessible to children.

Side Effects of Methotrexate

Methotrexate injection functions as an inhibiting agent that curbs the growth of cancerous cells and prevents them from using folic acid, which is an important nutrient in the cells, to regenerate new genetic material. The injection also prevents the growth and multiplication of these harmful cells. However, there are a few side effects but its overdose or prolonged use of this drug can lead to multiple organ damage in the body.

• This medication may have adverse effects on the digestive system. Individuals may complain of experiencing acute diarrhea. This condition may be characterized but loose or watery stools. Some individuals may also suffer from stomach ulcers, blisters in the intestine, which may lead to black, tarry stools as a result of internal bleeding. Vomiting induced nausea, blisters in the mouth and lips, and vomiting blood are some other side effects of an overdose of methotrexate shots.
• This medication may also lead to thinning of hair, appearance of blisters on the skin, and acne. Other side effects include skin rash, discoloration of the skin and photo sensitivity.
• Methotrexate treatment may lead to reduction in the blood count, resulting in anemia and formation of lumps in the lymph nodes.
• Individuals on a prolonged dose of methotrexate are more prone to infections like pneumonia, nocardiosis and sepsis.
• Other side effects include muscle and joint pain, mild tiredness and headache, ranging from mild to severe.

Methotrexate injection must not be taken by women planning a pregnancy or already pregnant, since this may harm the fetus and lead to congenital defects and sometimes even miscarriage. Always consult a health care practitioner before taking any injection, as a precautionary measure.